letrozole femara breast cancer

Eating healthily and being activecan help you keep to a healthy weight. Your doctor, nurse or a dietitian can give you more advice. If your skin feels dry, try using an unperfumed moisturising cream every day. Let your doctor or nurse know if you notice any changes.

  • This is better for sperm transport in the cervix and a more favourable lining for implantation.
  • Some patients may require higher doses and others may not ovulate at all.
  • If you’re taking letrozole to treat breast cancer that has come back or spread to another part of the body, you’ll usually take it for as long as it’s keeping the cancer under control.
  • Your doctor may give you medicines to control your cholesterol levels.
  • Letrozole (Femara®) is a hormonal therapy drug used to treat breast cancer.

Anastrozole, letrozole and exemestane are third generation AIs, and often decrease circulating oestrogen to undetectable levels, thereby reducing tumour proliferation and growth [2]. Moreover, AI therapy has been demonstrated to reduce the rate of mortality in breast cancer by up to 40% [3]. However, as we will see in the next section, joint pain is one of the most common side effects.


The women in the intermittent group took letrozole once a day for 9 months followed by 3 months of no treatment, for 4 years. If you want to stop taking letrozole for any reason, your doctor will be able to discuss alternatives for treating your breast cancer or preventing it coming back. Side effects caused by letrozole will be different for each person.

Experts in the UK have produced guidelines for health care professionals on managing the bone health of women on breast cancer treatments. These guidelines help to identify those who need to have a bone density scan and treatment for osteoporosis. Studies have shown that during two years of goserelin treatment, pre-menopausal women can lose 5 to 10% of bone density. https://www.klimaplovdiv.bg/2023-uk-steroid-shops-ranked-top-picks-for-quality/ (Femara) is type of hormone therapy called an aromatase inhibitor. When this trial was done, it was common to have hormone therapy such as tamoxifen for 5 years after surgery. And research had shown that having letrozole for another 5 years, after the first 5 years of hormone therapy, may further reduce the risk of the cancer coming back.

Postmenopausal women

You may be prescribed letrozole on its own or letrozole and another breast cancer medicine called tamoxifen. You may also experience side effects caused by other treatments or individual circumstance, such as the menopause. If you’re worried about any long term side effects after stopping letrozole, speak to your treatment team or GP.

  • If this happens, tell your doctor so they can give you painkillers.
  • Some patients with irregular periods may be asked to attend on different days of the cycle to try to determine whether ovulation has occurred.
  • Staff are available to give advice about stopping smoking, please ask about this.
  • We have based this summary on information from the research team.

Although plenty of rest is important, between these times it is better to be active. Although this seems a great effort at first, patients often find their overall levels of fatigue are reduced by light exercise. If the scansshow that your ovaries have over-stimulated, the dose of Letrozole may be reduced in your next cycle. You will be advised to have protected intercourse (with condoms) to avoid the risk of a multiple pregnancy. Please let the fertility team know if you feel unwell.

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N2 – Letrozole is a type 2 aromatase inhibitor, which reduces availability of estrogen in postmenopausal women, thereby decreasing its ability to stimulate breast cancer cells. Letrozole belongs to a class of drugs called aromatase inhibitors. The prime and only licensed use of Letrozole is as an additional (adjuvant) treatment of breast cancer in post-menopausal women.

Sometimes people are given a short break from letrozole. This can help if you’re getting side effects such as joint pain. However, only take a break from your medicine if you’ve discussed it with your specialist first and they agree to it. You may feel like your heart is racing (heart palpitations) when taking letrozole, which is more common in older people.

The level of drug in your body will remain high enough from the day before. Some brands of letrozole contain small amounts of lactose. If you know you are lactose intolerant discuss this with your treatment team or pharmacist. Letrozole is usually given after surgery to reduce the risk of breast cancer coming back or spreading.

Raised blood pressure

It can also be given to treat breast cancer that has spread to another part of the body (secondary breast cancer), when it’s often given alongside another drug. Stopping the ovaries producing oestrogen using surgery, drugs or radiotherapy. Men with breast cancer may be given letrozole, although another drug called tamoxifen is more commonly used.